Two isoforms of cyclooxygenase exist:
Both catalyze the reaction that converts arachidonic acid into a class of hormones known as eicosinoids, which include prostaglandins, prostacyclins, and thromboxanes.
COX-1 is expressed in all mammalian tissues, and serves a variety of homeostatic physiologic functions. It is responsible for the production of protective prostaglandins in the kidney and the stomach, as well as the functional thromboxane of platelets.
COX-2 is not normally found in most tissues, and is expressed under conditions of tissue damage. COX-2 leads to the biosynthesis of prostaglandins, triggering pain and inflammatory responses.
COX Selective Inhibitors
A form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Selectivity for COX-2 reduces the risk of peptic ulceration when taken over extended periods of time.
It has been discovered that a blue-green algae extract and, more particularly, phycocyanin functions as a COX-2 inhibitor that is effective in treating arthritis and other inflammatory conditions in animals. The use of phycocyanin is now patented and effective in reducing inflammation in animals through its ability to selectively inhibit the COX-2 enzyme. 1, 2, 3
41 horses with moderate to severe arthritis and inflammatory conditions showed statistically significant, owner-perceived improvements in:
- activity level
- ability to change position from lying down to standing
- pain level
- general activity
- 80% of the horses experienced some benefit within thirty days of Phycox® use
- 93% responded after four months2
Safe for Use in Horses
In testing, horses fed up to 12 times the recommended label dosage of Phycox® for 120 days experienced no dose-related adverse effects.3 Phycox®-EQ has all the joint support benefits of many commonly used products, plus scientific research has shown Phycox® to be effective at reducing pain and inflammation in horses.1, 2, 3