Questions? Call 877-813-7387 Mon-Fri 8am - 5pm CT
Click for details
close ×

Save 5% With Autoship

Autoship is an easy way for items to be automatically delivered on a regular schedule. Autoship is easily managed online and can be canceled at anytime. Simply choose how often you want to receive your items, and it will be automatically delivered to your doorstep. A 5% discount is applied to all autoship orders. Shipping is included on orders over $69.
An email reminder is sent 3 days before the autoship is scheduled for shipment. Order frequency, next order date and/or quantity can be changed in the 'autoship' section in your account. Changes to orders may be made anytime within 24 hours of the next scheduled order date.

See all Autoship details »


Part Number:8900|


Manufacturer Varies
  • Competitively inhibits histamine binding at the H1 receptors
  • Antihistamine
  • Used to prevent motion sickness in dogs
  • Relieves respiratory allergies and itching

Manufacturer Varies, Product Label may be different than shown.

Your Price: $24.99
In Stock

Choose Options

50 mg x 1000 ct


Diphenhydramine is an antihistamine that competitively inhibits histamine binding at the H1 receptors. Antihistamines do not block the release of histamine but compete for uptake at the receptors on sensitive cells in the respiratory tract, intestines, blood vessels and skin.

Diphenhydramine is used in companion-animal practice to treat allergies and atopy primarily in dogs. Antihistamines alone can control pruritis in 20-40% of atopic dogs. If antihistamines are unable to control all of the allergic signs, they may be used with corticosteroids, allowing use of a lower dose of the corticosteroids. The sedative effects seen with diphenhydramine use also may help with agitation associated with allergic symptoms. Antihistamines should not be used within a week of skin testing for allergies.

Diphenhydramine also may be used as an antiemetic and frequently is used to prevent motion sickness in dogs. H1 histaminergic receptors play a role in the emetic response associated with motion sickness in dogs (but not in cats). Diphenhydramine will cause some central nervous system (CNS) depression and sedation, although the sedative effects may diminish with time. When using oral diphenhydramine for motion sickness, it should be given 30 to 60 minutes before traveling.

H1 blockers such as diphenhydramine and H2 blockers such as ranitidine or cimetidine are used in dogs prior to surgical excision of mast cell tumors in order to prevent some of the effects of massive histamine release due to mast cell de-granulation. These drugs generally are continued during the recovery period in order to improve wound healing.

Diphenhydramine also is used to treat neurotoxicity or extrapyrimidal effects due to phenothiazines, metoclopramide and tremors due to organophosphate or carbamate poisoning. Chlorpheniramine is the antihistamine-of-choice for pruritis, alopecia and motion sickness in cats. Manufacturer may vary from product shown.

Manufacturer may vary from product shown.