Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.
Additionally, corticosteroids administered to dogs, rabbits and rodents during pregnancy have
resulted in cleft palate in the offspring. In dogs, other congenital anomalies have resulted:
deformed forelegs, phocomelia, and anasarca.
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control
Center right away.
Animax Ointment is not intended for the treatment of deep abscesses or
deep-seated infections such as inflammation of the lymphatic vessels. Parenteral antibiotic
therapy is indicated in these infections.
Animax Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment)
has been extremely well tolerated. Cutaneous reactions attributable to its use have been
extremely rare. The occurrence of systemic reactions is rarely a problem with topical
administration. There is some evidence that corticosteroids can be absorbed after topical
application and cause systemic effects. Therefore, an animal receiving Animax Ointment therapy
should be observed closely for signs such as polydipsia, polyuria, and increased weight gain.
Animax Ointment is not generally recommended for the treatment of deep or puncture wounds
or serious burns.
Sensitivity to neomycin may occur. If redness, irritation, or swelling persists or increases,
discontinue use. Do not use if pus is present since the drug may allow the infection to spread.
Avoid ingestion. Oral or parenteral use of corticosteroids (depending on dose, duration of use,
and specific steroid) may result in inhibition of endogenous steroid production following drug
SAP and SGPT (ALT) enzyme elevations, polydipsia and polyuria, vomiting,
and diarrhea (occasionally bloody) have been observed following parenteral or systemic use of
synthetic corticosteroids in dogs.
Cushing's syndrome has been reported in association with prolonged or repeated steroid
therapy in dogs.
Temporary hearing loss has been reported in conjunction with treatment of otitis with products
containing corticosteroids. However, regression usually occurred following withdrawal of the
drug. If hearing dysfunction is noted during the course of treatment with Animax Ointment,
discontinue its use.
Before instilling any medication into the ear, examine the external ear canal
thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility
of transmitting infection to the middle ear as well as damaging the cochlea or vestibular
apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course
of treatment, discontinue the use of Animax Ointment.