Directions:
Give Furosemide to your pet as directed by your veterinarian. Give this medicine with meals. Try to give this medicine at about the same time each day. DO NOT give your pet more medicine than directed or prescribed. Try not to miss giving any doses.

Dosage and Administration:
The usual dosage of Furosemide Tablets is 1 to 2 mg/lb body weight (approximately 2.5 to 5 mg/kg). A prompt diuresis usually ensues from the initial treatment.

Administer orally once or twice daily at 6 to 8 hour intervals. The dosage should be adjusted to the individual's response. In severe edematous or refractory cases the dose may be doubled or increased by increments of 1.0 mg per pound of body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian. Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dose schedule i.e. every other day or 2 to 4 consecutive days weekly.

Diuretic therapy should be discontinued after reduction of the edema or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment the dose can generally be lowered after the edema has once been reduced. Re-examination and consultations with the client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN C02 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.

Precautions:
Furosemide Tablets are a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance. Therefore the dosage and schedule may have to be adjusted to the patient's need. The animal should be observed for early signs of electrolyte imbalance and corrective measures administered. Early signs of electrolyte imbalance are increased thirst lethargy drowsiness or restlessness fatigue oliguria gastro-intestinal disturbances and tachycardia. Special attention should be given to potassium levels. Furosemide Tablets may lower serum calcium levels and cause tetany in rare cases of animals having an existing hypocalcemic tendency. Furosemide Tablets are contraindicated in anuria. Therapy should be discontinued in cases of progressive renal disease if increasing azotemia and oliguria occur during the treatment. Sudden alterations of fluid and electrolyte imbalance in an animal with cirrhosis may precipitate hepatic coma therefore observation during period of therapy is necessary. In hepatic coma and in states of electrolyte depletion therapy should not be instituted until the basic condition is improved or corrected. Potassium supplementation may be necessary in cases routinely treated with potassium-depleting steroids.

Active or latent diabetes may on rare occasions be exacerbated by furosemide. Transient loss of auditory capacity has been experimentally produced in cats following intravenous injections of excessive doses of furosemide at a very rapid rate.

Warning:
Furosemide Tablets are a highly effective diuretic and if given in excessive amounts as with any diuretic may lead to excessive diuresis which could result in electrolyte imbalance dehydration and reduction of plasma volume enhancing the risk of circulatory collapse thrombosis and embolism. Therefore the animal should be observed for early signs of fluid depletion with electrolyte imbalance and corrective measures administered. Excessive loss of potassium in patients receiving digitalis or its glycosides may precipitate digitalis toxicity. Caution should be exercised in animals administered potassium-depleting steroids. Correct potassium deficiency with proper dietary supplementation. If animal needs potassium supplements use oral liquid form do not use enteric-coated potassium tablets. The concurrent use of furosemide with some antibiotics may be inadvisable. There is evidence that the drug enhances the nephrotoxic potential of aminoglycosides cephalosporins and polymyxins and increases the ototoxic effects of aminoglycosides. Sulfonamide diuretics have been reported to decrease arterial responsiveness to pressor amines and to enhance the effect of tubocurarine. Caution should be exercised in administering curare or its derivatives to patients undergoing therapy with Furosemide Tablets and it is advisable to discontinue Furosemide Tablets for one day prior to any elective surgery.

Indications:
Dogs: Furosemide Tablets are indicated for the treatment of edema (pulmonary congestion ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. In cases of edema involving cardiac insufficiency the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy is determined by the clinical pathology producing the edema.

Contraindications:
Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant animals. Furosemide is contraindicated in anuria furosemide hypersensitivity hepatic coma or during electrolytic imbalances. Monitor serum electrolytes BUN and C02 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia. Corticosteroids cause an additive potassium-depletion effect.

Prescription

This item requires a valid prescription from a licensed veterinarian. Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

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