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Vanguard DAPP/L4 + CV

Vanguard DAPP/L4 + CV
Vanguard DAPP/L4 + CV
Part Number:5596|




  • Prevention of canine distemper, hepatitis, respiratory disease, parainfluenza, enteritis, and leptospirosis
  • For dogs 6 weeks of age or older
  • Subcutaneous vaccination
Notice NOTICE: This item requires special shipping!

OVERNIGHT SHIPPING ONLY due to the perishable nature of this product. Same day shipping only on orders placed before Monday 11 AM CT and Tuesday 11 AM CT. Orders placed after Tuesday 11 AM CT will be shipped the following Monday. Overnight money-back delivery service guarantee has been suspended by FedEx and UPS our third-party carriers due to work and travel restrictions in response to the impact of Covid-19 around the world. No shipments on holidays. Contact Customer Service for questions.

When outside temperatures reach extreme limits please contact customer service to order.

Packaging may vary

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25 x 1 mL Tray

Vanguard DAPP/L4 + CV previously Vanguard® Plus 5 L4 Cv

Manufacturer: Zoetis, Inc.
This treatment applies to Dogs.
Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine
Modified Live and Killed Virus
Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin
For use in dogs only
Thimerosal free

For vaccination of healthy dogs 6 weeks of age or older as an aid in preventing disease caused by CD virus, CAV-1, CAV-2, CPI virus, CCV, CPV and CPV-2c, Leptospira canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona. Vanguard DAPP/L4 + CV contains attenuated strains of CD virus, CAV-2, CPI virus, CPV, inactivated CCV, and inactivated whole cultures of the four Leptospira serovars mentioned above. The high-titer, low-passage CPV virus in Vanguard DAPP/L4 + CV is highly immunogenic and capable of stimulating active immunity in the presence of maternal antibodies. This product does not contain CPV type 2c. Cross protection against CPV type 2c was demonstrated in vaccinated puppies challenged 5 weeks following second vaccination.

Vaccination and revaccination according to label directions have been demonstrated (under field conditions) to result in serum antibody titers that persist for 12-48 months against CV virus (serum neutralization [SN] titer = 1:32), CAV- 1 (SN = 1:16), CAV-2 (SN = 1:16), CPI virus (SN = 1:16), and CPV (hemagglutination inhibition [HAI] titer = 1:80).

Vanguard DAPP/L4 + CV is a freeze-dried preparation of attenuated strains of CD virus, CAV-2, CPI virus, CPV and inactivated whole cell cultures of L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, and L. pomona.
The Leptospirosis fraction is microfiltered 5 times to remove extraneous protein, providing excellent antigen purity and smoothness.
Efficacy confirmed against the most common canine Leptospira serovars.


California Residents: Click Here For Proposition 65 Warning »
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CALIFORNIA PROPOSITION 65 WARNING: This product contains chemicals which are known to the State of California to cause cancer, birth defects or other reproductive harm. (California law requires this warning to be given to customers in the state of California) For more information go to

A valid veterinarian prescription is required to purchase this item in the state of Minnesota. Please contact your veterinarian for a prescription.